No. MiniDSP kits only require software configuration at the initialization. Once the board configured, the configuration is automatically saved to the board and will be reloaded after any power cycle. The board does not have to be connected to a USB from a PC source anymore. A miniUSB charger will serve the same purpose of providing DC power to the board. We recommend this being said that you make sure to select a good quality charger to keep the noise as low as possible.